Trace fear conditioning involves hippocampal 5 GABAA receptors
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چکیده
منابع مشابه
Muscarinic Receptors in Amygdala Control Trace Fear Conditioning
Intelligent behavior requires transient memory, which entails the ability to retain information over short time periods. A newly-emerging hypothesis posits that endogenous persistent firing (EPF) is the neurophysiological foundation for aspects or types of transient memory. EPF is enabled by the activation of muscarinic acetylcholine receptors (mAChRs) and is triggered by suprathreshold stimula...
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We examined the effects of acute injections of competitive N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-5-phosphonovaleric acid (APV) into the dorsal hippocampus on contextual fear conditioning and classical eyeblink conditioning in C57BL/6 mice. When injected 10 to 40 min before training, APV severely impaired contextual fear conditioning. Thus, APV injection under these conditions ...
متن کاملTrace fear conditioning in mice.
In this experiment we present a technique to measure learning and memory. In the trace fear conditioning protocol presented here there are five pairings between a neutral stimulus and an unconditioned stimulus. There is a 20 sec trace period that separates each conditioning trial. On the following day freezing is measured during presentation of the conditioned stimulus (CS) and trace period. On...
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Trace fear conditioning is enhanced in mice lacking the subunit of the GABAA receptor Brian J. Wiltgen, Matthew J. Sanders, Carolyn Ferguson, Gregg E. Homanics, and Michael S. Fanselow Psychology Department, and The Brain Research Institute, UCLA, Los Angeles, California 90095, USA; Department of Anesthesiology, and Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsb...
متن کاملAuditory trace fear conditioning requires perirhinal cortex.
The hippocampus is well-known to be critical for trace fear conditioning, but nothing is known about the importance of perirhinal cortex (PR), which has reciprocal connections with hippocampus. PR damage severely impairs delay fear conditioning to ultrasonic vocalizations (USVs) and discontinuous tones (pips), but has no effect on delay conditioning to continuous tones. Here we demonstrate that...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2002
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.142288699